Dr Casey Theriot
Dr. Theriot’s research focuses on defining the gastrointestinal tract microbiome and metabolome during different disease states to understand how perturbations to this system affect human health. Colonization resistance describes the ability of the gastrointestinal tract to prevent colonization by pathogens. Currently, she is exploring the interactions between the gut microbiota and the pathogen Clostridium difficile, a significant and re-emerging public health problem. C. difficile infection (CDI) is the leading nosocomial infection in the United States. A major goal of her work is to create an integrated model of the complex interactions among the gut microbiota, pathogen and host. To accomplish this she integrates data obtained from high-throughput methods that analyze the gut microbiome, metabolome and host immune responses in mouse models and human biological specimens.