Exercise is perhaps the single “intervention” recognized as a deterrent to systemic diseases such as osteoporosis, sarcopenia, diabetes and obesity, yet the manner in which mechanical signals inhibit their pathogenesis remains unknown. In an effort to understand what aspects of exercise are critical to the achievement and retention of musculoskeletal wellness, our work has led us to focus on how brief daily periods of high frequency-low intensity vibration (LIV) is anabolic to both bone and muscle. These signals serve as a surrogate for the spectrum of low-level mechanical signals provided b
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