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Autism One: A Conversation of Hope

Autism One: A Conversation of Hope

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March 31st 2009:Mast cells disrupt the gut-blood-brain barriers and contribute to autism

Join Teri as she asks Dr. Theoharides about the role of mast cells in autism and other conditions. Many ASD patients have a history of "allergic" symptoms and food intolerance, suggesting activation of mast cells, now recognized as master regulators of the immune system. Activation of intestinal and brain mast cells by immune, infectious, stress or toxic triggers could lead to gut-blood-brain-barrier disruption, permitting brain inflammation and autism. Theoharis Theoharides, MD, PhD, is a professor of pharmacology, internal medicine and biochemistry, and the director of the Laboratory of Mole

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Theoharis Theoharides, MD, PhD

Dr. Theoharides about the role of mast cells in autism and other conditions. Many ASD patients have a history of "allergic" symptoms and food intolerance, suggesting activation of mast cells, now recognized as master regulators of the immune system. Activation of intestinal and brain mast cells by immune, infectious, stress or toxic triggers could lead to gut-blood-brain-barrier disruption, permitting brain inflammation and autism. Theoharis Theoharides, MD, PhD, is a professor of pharmacology, internal medicine and biochemistry, and the director of the Laboratory of Molecular Immunopharmacology and Drug Discovery; Department of Pharmacology and Experimental Therapeutics, Tufts University Sc
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