Mast cells disrupt the gut-blood-brain barriers and contribute to autism

March 31, 2009
Hosted by Teri Arranga

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Episode Description

Join Teri as she asks Dr. Theoharides about the role of mast cells in autism and other conditions. Many ASD patients have a history of "allergic" symptoms and food intolerance, suggesting activation of mast cells, now recognized as master regulators of the immune system. Activation of intestinal and brain mast cells by immune, infectious, stress or toxic triggers could lead to gut-blood-brain-barrier disruption, permitting brain inflammation and autism. Theoharis Theoharides, MD, PhD, is a professor of pharmacology, internal medicine and biochemistry, and the director of the Laboratory of Molecular Immunopharmacology and Drug Discovery; Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine. This will be a fascinating and informative interview.

Autism One: A Conversation of Hope

Autism One: A Conversation of Hope

Archives Available on VoiceAmerica Health and Wellness Channel

Approximately 1 child in 50 is diagnosed with autism, which gives autism the undesired ranking as the most prevalent childhood developmental disorder in the United States. 67 children will be diagnosed today - that is nearly 1 child every 20 minutes. Autism is treatable and children are significantly improving or recovering following appropriate therapies. “Autism One: A Conversation of Hope” hosted by Teri Arranga, includes discussions with the most experienced doctors, researchers, and therapists in the field, parents of recovered children, and advocates for the children and families.

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Teri Arranga

Teri Arranga

Teri Arranga is the executive director of AutismOne (www.autismone.org), the vice president of the Global Autism Collaboration (www.autism.org), and the secretary of Strategic Autism Initiative. She has served as the editor-in-chief of Autism Science Digest and as editor of the US/Canada edition of Autism File magazine. Teri is co-editor of the book Bugs, Bowels, and Behavior: The Groundbreaking Story of the Gut-Brain Connection, and she is editor of Dr. William Walsh's book Nutrient Power and Dr. Andrew Wakefield's books Callous Disregard: Autism and Vaccines - The Truth Behind a Tragedy (www.callous-disregard.com) and Waging War on the Autistic Child: The Arizona 5 and the Legacy of Baron von Munchausen, all of which were published by Skyhorse Publishing. Additionally, Teri has contributed to and provided editing for all annual editions of Skyhorse Publishing's Cutting-Edge Therapies for Autism series. Teri has been involved with a number of media projects, including consulting for medical documentaries such as by award-winning filmmaker Lina Moreco of Canada, appearing in the award-winning documentary Beautiful Son, and consulting for the April 2007 Discover magazine article "Understanding Autism." Teri received the National Autism Association's Believe Award for 2008 and a volunteerism award from USAAA in 2006. She has been an active advocate in the autism community for many years, including attending and broadcasting events in Washington, D.C.

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